Sead Kolasinac drops to the bench with Ainsley Maitland-Niles continuing at left-back and Jack Wilshere makes his second consecutive Premier League start next to Granit Xhaka in central midfield.
Newcastle meanwhile welcome back Rob Elliot in goal and manager Rafa Benitez hands a start to former Arsenal midfielder Issac Hayden, with Jonjo Shelvey missing out through suspension.
Arsenal: Cech; Bellerin, Koscielny, Monreal, Maitland-Niles; Iwobi, Xhaka, Wilshere; Ozil, Alexis; Lacazette.Newcastle: Arsenal: Elliot, Yedlin, Lascelles, Lejeune, Manquillo, Murphy, Hayden, Merino, Atsu, Perez, Joselu.