Wenger makes four changes from the 2-0 win over Southampton in midweek, handing opportunities to Hector Bellerin, Francis Coquelin, and Giroud, while Laurent Koscielny makes his return after a spell on the sidelines with a calf injury.
Aaron Ramsey and Danny Welbeck are dropped to the bench despite starting on Wednesday, while left-back Kieran Gibbs and versatile midfielder Alex Oxlade-Chamberlain are both reportedly absent due to hamstring problems.
Arsenal XI: Cech; Holding, Mustafi, Koscielny; Bellerin, Coquelin, Xhaka, Monreal; Ozil, Sanchez; Giroud.Subs: Ospina, Gabriel, Ramsey, Walcott, Iwobi, Welbeck, Elneny.
